Bone marrow aspiration of plasmablastic multiple myeloma

The bone marrow on sternal aspiration in multiple myeloma.

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

In vitro Effect of Pomalidomide on Bone Marrow Mononuclear Cells from Multiple Myeloma Patients

Background: Many features of anticancer drugs, including cytotoxicity and/or cytokine induction, are studied using cell lines orhuman blood leukocytes. However, in a disease such as multiple myeloma, most cancerous cells are resided within bone marrowmononuclear cells. In the present study, we investigated the effect of pomalidomide on apoptosis and IL-2 production of bonemarrow mononuclear cel...

Bone Marrow Microenvironment in Multiple Myeloma Progression

Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteo...

The sternal marrow aspiration of amyloid in multiple myeloma.

By SIDNEY TRUBOWITZ, M.D. T HE OCCURRENCE of amyloidosis in multiple myeloma has been long recognized and the association of the two conditions well established. In 1931, Magnus-Levy’ wrote : ‘ ‘When I, at first purely out of interest in the clinical and metabolic aspects of myeloma, dug deeper into the literature, I was surprised to find a rather large, constantly growing body of data on amylo...